Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells.

ABSTRACT:

Background

Autophagy plays important roles in odontogenic differentiation of dental pulp cells (DPCs) in the developmental stage of tooth bud. Few studies have reported the role of autophagy during reparative dentin formation process. The objective of this study was to discover gene expression pattern correlated to autophagy and their role during odontogenic differentiation process in DPCs.

Methods

After tooth cavities were prepared on the mesial surface of lower first molar crown of rats. Odontogenic differentiation and reparative dentin formation were assessed based on detection of morphology change with hematoxylin and eosin staining.

Results

After tooth cavities were prepared on the mesial surface of lower first molar crown of rats, odontogenic differentiation and

SUBMITTER: Cho HS 

PROVIDER: S-EPMC8012421 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature