TNF-α-Inhibition Improves the Biocompatibility of Porous Polyethylene Implants In Vivo.

ABSTRACT:

Background

To improve the biocompatibility of porous polyethylene (PPE) implants and expand their application range for reconstructive surgery in poorly vascularized environments, implants were coated with tumor necrosis factor α (TNFα) inhibitor Etanercept. While approved for systemic application, local application of the drug is a novel experimental approach. Microvascular and mechanical integration as well as parameters of inflammation were analyzed in vivo.

Methods

PPE implants were coated with Etanercept and extracellular matrix (ECM) components prior to implantation into dorsal skinfold chambers of C57BL/6 mice. Fluorescence microscopy analyses of angiogenesis and local inflammatory response were thrice performed in vivo over a period of 14 days to assess tissue integr

SUBMITTER: Hussain T 

PROVIDER: S-EPMC8012447 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature