Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation.

ABSTRACT: Tissue-resident stem cells are surrounded by a microenvironment known as 'stem cell niche' which is specific for each stem cell type. This niche comprises of cell-intrinsic and -extrinsic factors like biochemical and biophysical signals, which regulate stem cell characteristics and differentiation. Biochemical signals have been thoroughly studied however, the effect of biophysical signals on stem cell regulation is yet to be completely understood. Biomaterials have aided in addressing this issue since they can provide a defined and tuneable microenvironment resembling in vivo conditions. We review various biomaterials used in many studies which have shown a connection between biomaterial-generated mechanical signals and alteration in stem cell behaviour. Researchers probed to understand th

SUBMITTER: Virdi JK 

PROVIDER: S-EPMC8012461 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature