Carbohydrate-controlled serine protease inhibitor (serpin) production in Bifidobacterium longum subsp. longum.

ABSTRACT: The Serine Protease Inhibitor (serpin) protein has been suggested to play a key role in the interaction of bifidobacteria with the host. By inhibiting intestinal serine proteases, it might allow bifidobacteria to reside in specific gut niches. In inflammatory diseases where serine proteases contribute to the innate defense mechanism of the host, serpin may dampen the damaging effects of inflammation. In view of the beneficial roles of this protein, it is important to understand how its production is regulated. Here we demonstrate that Bifidobacterium longum NCC 2705 serpin production is tightly regulated by carbohydrates. Galactose and fructose increase the production of this protein while glucose prevents it, suggesting the involvement of catabolite repression. We identified that di- and

SUBMITTER: Duboux S 

PROVIDER: S-EPMC8012564 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature