The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis.

ABSTRACT:

Background

Aging induced chronic systemic inflammatory response is an important risk factor for atherosclerosis (AS) development; however, the detailed mechanism is yet to be elucidated.

Objective

To explore the underlying mechanism of how aging aggravates AS advancement.

Methods

A young (five-week-old, YM) and aged group (32-week-old, OM) male apoE^-/- mice with a high fat diet were used as models, and age-matched male wild-type C57BL/6J (WT) mice were used as controls. AS lesion size, serum lipid profile, cytokines, and gut microbiota-derived LPS were analyzed after 32 weeks of diet intervention. A correlation analysis between the 16S rRNA sequencing of the feces and serum metabolomics profiles was applied to examine the effect of their interactions on AS.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC8012722 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature