White matter alterations in the brains of patients with active, remitted, and cured cushing syndrome: a DTI study.

ABSTRACT:

Background and purpose

Cushing syndrome appears after chronic exposure to elevated glucocorticoid levels. Cortisol excess may alter white matter microstructure. Our purpose was to study WM changes in patients with Cushing syndrome compared with controls by using DTI and the influence of hypercortisolism.

Materials and methods

Thirty-five patients with Cushing syndrome and 35 healthy controls, matched for age, education, and sex, were analyzed through DTI (tract-based spatial statistics) for fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity (general linear model, family-wise error, and threshold-free cluster enhancement corrections, P < .05). Furthermore, the influence of hypercortisolism on WM DTI changes was studied by comparing 4 subgroups:

SUBMITTER: Pires P 

PROVIDER: S-EPMC8013026 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature