Progression of microstructural damage in spinocerebellar ataxia type 2: a longitudinal DTI study.

ABSTRACT:

Background and purpose

The ability of DTI to track the progression of microstructural damage in patients with inherited ataxias has not been explored so far. We performed a longitudinal DTI study in patients with spinocerebellar ataxia type 2.

Materials and methods

Ten patients with spinocerebellar ataxia type 2 and 16 healthy age-matched controls were examined twice with DTI (mean time between scans, 3.6 years [patients] and 3.3 years [controls]) on the same 1.5T MR scanner. Using tract-based spatial statistics, we analyzed changes in DTI-derived indices: mean diffusivity, axial diffusivity, radial diffusivity, fractional anisotropy, and mode of anisotropy.

Results

At baseline, the patients with spinocerebellar ataxia type 2, as compared with controls, showed numerou

SUBMITTER: Mascalchi M 

PROVIDER: S-EPMC8013027 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature