Vasodilatory capacity of the cerebral vasculature in patients with carotid artery stenosis.

ABSTRACT:

Background and purpose

Impairment of the cerebral autoregulation is an important predictor of TIA and stroke in patients with an ICA stenosis. The autoregulative status can be assessed directly by measuring the vasodilatory capacity of the cerebral arteries. The aim of our study was to investigate the vasodilatory capacity of the proximal and distal cerebral vasculature in patients with an ICA stenosis and healthy control subjects by combining MRA with an acetazolamide provocation challenge.

Materials and methods

Fourteen functionally independent patients (mean age, 67.2 ± 8.7 years) with a symptomatic ICA stenosis and 19 healthy controls (mean age, 63.1 ± 7.2 years) were included. MRA was performed before and 20 minutes after intravenous administration of acetazolamide. The

SUBMITTER: Bokkers RP 

PROVIDER: S-EPMC8013134 | biostudies-literature | 2011 Jun-Jul

REPOSITORIES: biostudies-literature