Factors driving availability of COVID-19 convalescent plasma: Insights from a demand, production, and supply model.

ABSTRACT:

Background

COVID-19 Convalescent Plasma (CCP) is a promising treatment for COVID-19. Blood collectors have rapidly scaled up collection and distribution programs.

Methods

We developed a detailed simulation model of CCP donor recruitment, collection, production, and distribution processes. We ran our model using varying epidemic trajectories from 11 U.S. states and with key input parameters drawn from wide ranges of plausible values to identify key drivers of ability to scale collections capacity and meet demand for CCP.

Results

Utilization of available CCP collections capacity followed increases in COVID-19 hospital discharges with a lag. Utilization never exceeded 75% of available capacity in most simulations. Demand was met for most of the simulation period in most

SUBMITTER: Russell WA 

PROVIDER: S-EPMC8013336 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature