COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis.

ABSTRACT:

Background

Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 has been increasingly recognized. However, the clinical features of MIS-C and the differences from Kawasaki disease remain unknown. The study aims to investigate the epidemiology and clinical course of MIS-C.

Methods

PubMed and EMBASE were searched through August 30, 2020. Observational studies describing MIS-C were included. Data regarding demographic features, clinical symptoms, laboratory, echocardiography and radiology findings, treatments, and outcomes were extracted. Study-specific estimates were combined using one-group meta-analysis in a random-effects model.

Results

A total of 27 studies were identified including 917 MIS-C patients. The mean age was 9.3 (

SUBMITTER: Yasuhara J 

PROVIDER: S-EPMC8013394 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature