Dataset Information

The COVID-19 epidemic in Madagascar: clinical description and laboratory results of the first wave, march-september 2020.

ABSTRACT:

Background

Following the first detection of SARS-CoV-2 in passengers arriving from Europe on 19 March 2020, Madagascar took several mitigation measures to limit the spread of the virus in the country.

Methods

Nasopharyngeal and/or oropharyngeal swabs were collected from travellers to Madagascar, suspected SARS-CoV-2 cases and contact of confirmed cases. Swabs were tested at the national reference laboratory using real-time RT-PCR. Data collected from patients were entered in an electronic database for subsequent statistical analysis. All distribution of laboratory-confirmed cases were mapped, and six genomes of viruses were fully sequenced.

Results

Overall, 26,415 individuals were tested for SARS-CoV-2 between 18 March and 18 September 2020, of whom 21.0% (5,553/26,145) returned positive. Among laboratory-confirmed SARS-CoV-2-positive patients, the median age was 39 years (IQR: 28-52), and 56.6% (3,311/5,553) were asymptomatic at the time of sampling. The probability of testing positive increased with age with the highest adjusted odds ratio of 2.2 [95% CI: 1.9-2.5] for individuals aged 49 years and more. Viral strains sequenced belong to clades 19A, 20A and 20B indicative of several independent introduction of viruses.

Conclusions

Our study describes the first wave of the COVID-19 in Madagascar. Despite early strategies in place Madagascar could not avoid the introduction and spread of the virus. More studies are needed to estimate the true burden of disease and make public health recommendations for a better preparation to another wave.

SUBMITTER: Randremanana RV

PROVIDER: S-EPMC8013501 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The COVID-19 epidemic in Madagascar: clinical description and laboratory results of the first wave, march-september 2020.

Randremanana Rindra Vatosoa RV Andriamandimby Soa-Fy SF Rakotondramanga Jean Marius JM Razanajatovo Norosoa Harline NH Mangahasimbola Reziky Tiandraza RT Randriambolamanantsoa Tsiry Hasina TH Ranaivoson Hafaliana Christian HC Rabemananjara Harinirina Aina HA Razanajatovo Iony I Razafindratsimandresy Richter R Rabarison Joelinotahiana Hasina JH Brook Cara E CE Rakotomanana Fanjasoa F Rabetombosoa Roger Mario RM Razafimanjato Helisoa H Ahyong Vida V Raharinosy Vololoniaina V Raharimanga Vaomalala V Raharinantoanina Sandratana Jonhson SJ Randrianarisoa Mirella Malala MM Bernardson Barivola B Randrianasolo Laurence L Randriamampionona Léa Bricette Nirina LBN Tato Cristina M CM DeRisi Joseph L JL Dussart Philippe P Vololoniaina Manuela Christophère MC Randriatsarafara Fidiniaina Mamy FM Randriamanantany Zely Arivelo ZA Heraud Jean-Michel JM

Influenza and other respiratory viruses 20210215 4

<h4>Background</h4>Following the first detection of SARS-CoV-2 in passengers arriving from Europe on 19 March 2020, Madagascar took several mitigation measures to limit the spread of the virus in the country.<h4>Methods</h4>Nasopharyngeal and/or oropharyngeal swabs were collected from travellers to Madagascar, suspected SARS-CoV-2 cases and contact of confirmed cases. Swabs were tested at the national reference laboratory using real-time RT-PCR. Data collected from patients were entered in an el ...[more]

PMID: 33586912

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Dataset Information

The COVID-19 epidemic in Madagascar: clinical description and laboratory results of the first wave, march-september 2020.

Background

Methods

Results

Conclusions

Publications

The COVID-19 epidemic in Madagascar: clinical description and laboratory results of the first wave, march-september 2020.

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