Soybean-associated endophytic fungi as potential source for anti-COVID-19 metabolites supported by docking analysis.

ABSTRACT:

Aims

To identify the metabolites produced by the endophytic fungus, Aspergillus terreus and to explore the anti-viral activity of the identified metabolites against the pandemic disease COVID-19 in-silico.

Methods and results

Herein, we reported the isolation of A. terreus, the endophytic fungus associated with soybean roots, which is then subcultured using OSMAC approach in five different culture media. Analytical analysis of media ethylacetate extracts using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) was carried out. Furthermore, the obtained LC-MS data were statistically processed with MetaboAnalyst 4.0. Molecular docking studies were performed for the dereplicated metabolites against COVID-19 main protease (M^pro ). Metabolom

SUBMITTER: El-Hawary SS 

PROVIDER: S-EPMC8013715 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature