Anti-Inflammatory (M2) Response Is Induced by a sp²-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (S _S,1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp²-iminosugar glycolipid (sp²-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. Moreover, pretreatment with (Ss)-DS-ONJ increased Heme-oxygenase (HO)-1 as well as interleukin 10 (IL10) expression in L

SUBMITTER: Cano-Cano F 

PROVIDER: S-EPMC8013727 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature