An Information Theoretical Multilayer Network Approach to Breast Cancer Transcriptional Regulation.

ABSTRACT: Breast cancer is a complex, highly heterogeneous disease at multiple levels ranging from its genetic origins and molecular processes to clinical manifestations. This heterogeneity has given rise to the so-called intrinsic or molecular breast cancer subtypes. Aside from classification, these subtypes have set a basis for differential prognosis and treatment. Multiple regulatory mechanisms-involving a variety of biomolecular entities-suffer from alterations leading to the diseased phenotypes. Information theoretical approaches have been found to be useful in the description of these complex regulatory programs. In this work, we identified the interactions occurring between three main mechanisms of regulation of the gene expression program: transcription factor regulation, regulation via nonc

SUBMITTER: Ochoa S 

PROVIDER: S-EPMC8014033 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature