Cytotoxicity, anti-microbial studies of M(II)-dithiocarbamate complexes, and molecular docking study against SARS COV2 RNA-dependent RNA polymerase.

ABSTRACT: Ten transition metal dithiocarbamate (DTC)complexes of the type [M(κ ²-Et₂DT)₂] (1-5), and [M(κ ²-PyDT)₂] (6-10) (where M = Co, Ni, Cu, Pd, and Pt; Et₂DT = diethyl dithiocarbamate; PyDT = pyrrolidine dithiocarbamate) were synthesized and characterized by different methods. The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions. The dithiocarbamate complexes showed good activity against the pathogen bacteria species. The results showed the Pt-dithiocarbamate complexes are more active against all the tested bacteria than the Pd-dithiocarbamate complex. The dithiocarbamate complexes displayed the m

SUBMITTER: Al-Janabi ASM 

PROVIDER: S-EPMC8014077 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature