Increased vulnerability to COVID-19 in chronic kidney disease.

ABSTRACT:

Background

The significance of chronic kidney disease on susceptibility to COVID-19 and subsequent outcomes remains unaddressed.

Objective

To investigate the association of estimated glomerular filtration rate (eGFR) on risk of contracting COVID-19 and subsequent adverse outcomes.

Methods

Rates of hospital-diagnosed COVID-19 were compared across strata of eGFR based on conditional logistic regression using a nested case-control framework with 1:4 matching of patients diagnosed with COVID-19 with controls from the Danish general population on age, gender, diabetes and hypertension. Risk of subsequent severe COVID-19 or death was assessed in a cohort study with comparisons across strata of eGFR based on adjusted Cox regression models with G-computation of results to det

SUBMITTER: Carlson N 

PROVIDER: S-EPMC8014284 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature