Ontology highlight
ABSTRACT:
SUBMITTER: Jangra S
PROVIDER: S-EPMC8014308 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Jangra Sonia S De Vrieze Jana J Choi Angela A Rathnasinghe Raveen R Laghlali Gabriel G Uvyn Annemiek A Van Herck Simon S Nuhn Lutz L Deswarte Kim K Zhong Zifu Z Sanders Niek N NN Lienenklaus Stefan S David Sunil A SA Strohmeier Shirin S Amanat Fatima F Krammer Florian F Hammad Hamida H Lambrecht Bart N BN Coughlan Lynda L García-Sastre Adolfo A De Geest Bruno G BG Schotsaert Michael M
Angewandte Chemie (International ed. in English) 20210311 17
The search for vaccines that protect from severe morbidity and mortality because of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19) is a race against the clock and the virus. Here we describe an amphiphilic imidazoquinoline (IMDQ-PEG-CHOL) TLR7/8 adjuvant, consisting of an imidazoquinoline conjugated to the chain end of a cholesterol-poly(ethylene glycol) macromolecular amphiphile. It is water-soluble and exhi ...[more]