A U-shaped association between baseline neutrophil count and COVID-19-related mortality: A retrospective cohort study.

ABSTRACT: Several descriptive studies have reported that higher neutrophil count (NC) may be correlated with poor prognosis in patients with confirmed COVID-19 infection. However, the findings from these studies are limited by methodology and data analysis. This study is a cohort study. We nonselectively and consecutively collected a total of 663 participants in a Chinese hospital from January 7 to February 28. Standardized and two-piecewise Cox regression model were employed to evaluate the association between baseline neutrophil count (bNC), neutrophil count change rate (NCR), and death. bNC had a U-shaped association with death. In the range of 0.1 to ≤1.49 × 10⁹ /L (hazard ratio [HR] = 0.19, 95% confidence interval [CI] = 0.05-0.66) and >3.55 × 10⁹ /L of bNC (HR = 2.82, 95%

SUBMITTER: Fu W 

PROVIDER: S-EPMC8014534 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature