Efficacy of corticosteroid in patients with COVID-19: A multi-center retrospective study and meta-analysis.

ABSTRACT: To evaluate the efficacy of corticosteroids on coronavirus disease 2019 (COVID-19) patients with different levels of disease severity. In our multicenter study, 543 patients with confirmed COVID-19 were classified as non-severe group and severe group, and then were compared respectively for all-cause mortality and length of hospital stay between those who received corticosteroids and not. By searching in PubMed, Web of Science, Embase, and CNKI, we identified 13 retrospective studies and 6 random control trials eligible for criteria of inclusion, and conducted comprehensive meta-analyses assessing the impacts of corticosteroids on mortality, length of stay, duration of RNA clearance and duration of fever. Our multicenter study demonstrated that low-dose corticosteroids can reduce mortality

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC8014848 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature