Inflammatory bowel disease and risk of severe COVID-19: A nationwide population-based cohort study in Sweden.

ABSTRACT:

Background

There are concerns that individuals with chronic immune-mediated diseases are at increased risk of COVID-19 and related severe adverse outcome, including intensive care admission or death. We aimed to explore the absolute and relative risk of severe COVID-19 in inflammatory bowel disease (IBD).

Methods

This population-based cohort study used nationwide registers in Sweden, with 67,292 individuals with a diagnosis of IBD 1969-2017 (Crohn's disease, n = 21,599; ulcerative colitis: n = 43,622; IBD-unclassified: n = 2071) and alive on 1 February 2020. Patients with IBD were matched to up to five controls from the general population (n = 297,910). Cox regression estimated hazard ratios (HRs) for (i) hospital admission with laboratory-confirmed COVID-19 as the primary d

SUBMITTER: Ludvigsson JF 

PROVIDER: S-EPMC8014882 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature