Intraoperative opioids are associated with improved recurrence-free survival in triple-negative breast cancer.

ABSTRACT:

Background

Opioid-induced immunomodulation may be of particular importance in triple-negative breast cancer (TNBC) where an immune response is associated with improved outcome and response to immunotherapy. We evaluated the association between intraoperative opioids and oncological outcomes and explored patterns of opioid receptor expression in TNBC.

Methods

Consecutive patients with stage I-III primary TNBC were identified from a prospectively maintained database. Opioid receptor expression patterns in the tumour microenvironment were analysed using publicly available bulk and single-cell RNA-seq data.

Results

A total of 1143 TNBC cases were retrospectively analysed. In multivariable analysis, higher intraoperative opioid dose was associated with favourable recurrenc

SUBMITTER: Montagna G 

PROVIDER: S-EPMC8014943 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature