Effects of perioperative oxygen concentration on oxidative stress in adult surgical patients: a systematic review.

ABSTRACT:

Background

The fraction of inspired oxygen (FiO₂) administered during general anaesthesia varies widely despite international recommendations to administer FiO₂ 0.8 to all anaesthetised patients to reduce surgical site infections (SSIs). Anaesthetists remain concerned that high FiO₂ administration intraoperatively may increase harm, possibly through increased oxidative damage and inflammation, resulting in more complications and worse outcomes. In previous systematic reviews associations between FiO₂ and SSIs have been inconsistent, but none have examined how FiO₂ affects perioperative oxidative stress. We aimed to address this uncertainty by reviewing the available literature.

Methods

EMBASE, MEDLINE, and Cochrane datab

SUBMITTER: Oldman AH 

PROVIDER: S-EPMC8014946 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature