An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer's disease.

ABSTRACT:

Background

Multiple pathophysiological processes have been described in Alzheimer's disease (AD). Their inter-individual variations, complex interrelations, and relevance for clinical manifestation and disease progression remain poorly understood. We hypothesize that specific molecular patterns indicating both known and yet unidentified pathway alterations are associated with distinct aspects of AD pathology.

Methods

We performed multi-level cerebrospinal fluid (CSF) omics in a well-characterized cohort of older adults with normal cognition, mild cognitive impairment, and mild dementia. Proteomics, metabolomics, lipidomics, one-carbon metabolism, and neuroinflammation related molecules were analyzed at single-omic level with correlation and regression approaches. Multi-omics

SUBMITTER: Clark C 

PROVIDER: S-EPMC8015070 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature