Tamper-Proof Time-Temperature Indicator for Inspecting Ultracold Supply Chain.

ABSTRACT: In the precarious situation caused by the COVID-19 pandemic, the use of messenger ribonucleic acid (mRNA) vaccines is promising for prevention against the infection. However, this type of vaccine has not been effectively commercialized because it needs to be stored and transported at ultracold conditions. mRNA vaccines exposed to undesired temperatures may not show any visible changes but can deteriorate and cause negative effects. Consumers' demand for vaccine authenticity requires logistics to develop a robust monitoring tool to ensure the integrity of ultracold supply chain from manufacturing until vaccination. Here, we report a time-temperature indicator (TTI) that can detect a relatively small change in temperature within subzero ranges, for example, from -70 to -60 °C, which cannot b

SUBMITTER: Hao LT 

PROVIDER: S-EPMC8015080 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature