Identification of blood-derived candidate gene markers and a new 7-gene diagnostic model for multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology and pathogenesis of MS remain unknown.

Results

In this study, the integration of three peripheral blood mononuclear cell (PBMC) microarray datasets and one peripheral blood T cells microarray dataset allowed comprehensive network and pathway analyses of the biological functions of MS-related genes. Differential expression analysis identified 78 significantly aberrantly expressed genes in MS, and further functional enrichment analysis showed that these genes were associated with innate immune response-activating signal transduction (p = 0.0017), neutrophil me

SUBMITTER: Chen X 

PROVIDER: S-EPMC8015180 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature