Betacellulin regulates peripheral nerve regeneration by affecting Schwann cell migration and axon elongation.

ABSTRACT:

Background

Growth factors execute essential biological functions and affect various physiological and pathological processes, including peripheral nerve repair and regeneration. Our previous sequencing data showed that the mRNA coding for betacellulin (Btc), an epidermal growth factor protein family member, was up-regulated in rat sciatic nerve segment after nerve injury, implying the potential involvement of Btc during peripheral nerve regeneration.

Methods

Expression of Btc was examined in Schwann cells by immunostaining. The function of Btc in regulating Schwann cells was investigated by transfecting cultured cells with siRNA segment against Btc or treating cells with Btc recombinant protein. The influence of Schwann cell-secreted Btc on neurons was determined using a co-

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8015203 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature