Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives.

ABSTRACT: The anteroposterior axial identity of motor neurons (MNs) determines their functionality and vulnerability to neurodegeneration. Thus, it is a crucial parameter in the design of strategies aiming to produce MNs from human pluripotent stem cells (hPSCs) for regenerative medicine/disease modelling applications. However, the in vitro generation of posterior MNs corresponding to the thoracic/lumbosacral spinal cord has been challenging. Although the induction of cells resembling neuromesodermal progenitors (NMPs), the bona fide precursors of the spinal cord, offers a promising solution, the progressive specification of posterior MNs from these cells is not well defined. Here, we determine the signals guiding the transition of human NMP-like cells toward thoracic ventral spinal cord neur

SUBMITTER: Wind M 

PROVIDER: S-EPMC8015249 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature