Idarucizumab (Praxbind^®) for dabigatran reversal in patients undergoing heart transplantation: a cohort of ten patients.

ABSTRACT:

Background

Novel oral anticoagulants are used in atrial fibrillation. Idarucizumab has been approved for reversal of dabigatran in situations of life-threatening hemorrhage or emergency surgery.

Objectives

We report a single center experience of ten patients on dabigatran therapy who were given idarucizumab prior to heart transplantation.

Methods & results

The mean plasma concentration of dabigatran prior to reversal was 139 ± 89 ng/ml. Hemoglobin, hematocrit and platelet levels were decreased after surgery. Surgical procedures were successfully performed with no increased risk, especially regarding bleeding complications. All patients were alive after 90 days.

Conclusion

Dabigatran reversal with idarucizumab in contexts of emergency surgery/urgent procedures i

SUBMITTER: Kalmanovich E 

PROVIDER: S-EPMC8015660 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature