Circulating miRNAs as early indicators of diet and physical activity response in women with metastatic breast cancer.
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ABSTRACT:
SUBMITTER: Olson J
PROVIDER: S-EPMC8015665 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Circulating miRNAs as early indicators of diet and physical activity response in women with metastatic breast cancer.
Olson Jessica J Sheean Patricia P Matthews Lauren L Chitambar Christopher R CR Banerjee Anjishnu A Visotcky Alexis A Bonini Marcelo M Stolley Melinda M
Future science OA 20210304 4
Treatments for metastatic breast cancer (MBC) improve survival but often impose prolonged symptom burden. We performed molecular characterization of 84 miRNAs in the circulating serum of women with MBC to explore possible early indicators of intervention response. Expression levels of miR-10a-5p and miR-211-5p were downregulated in nonresponders, but upregulated in responders (miR-10a-5p: 0.40-fold and eightfold; miR 211-5p: 0.47-fold and fourfold). miR-205-5p expression was upregulated in both ...[more]
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