Influenza Therapeutics in Clinical Practice-Challenges and Recent Advances.

ABSTRACT: In the last few years, several new direct-acting influenza antivirals have been licensed, and others have advanced in clinical development. The increasing diversity of antiviral classes should allow an adequate public health response should a resistant virus to one agent or class widely circulate. One new antiviral, baloxavir marboxil, has been approved in the United States for treatment of influenza in those at high risk of developing influenza-related complications. Except for intravenous zanamivir in European Union countries, no antivirals have been licensed specifically for the indication of severe influenza or hospitalized influenza. This review addresses recent clinical developments involving selected polymerase inhibitors, neuraminidase inhibitors, antibody-based therapeutics, and h

SUBMITTER: Beigel JH 

PROVIDER: S-EPMC8015700 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature