Plasma BDNF concentrations and the antidepressant effects of six ketamine infusions in unipolar and bipolar depression.

ABSTRACT:

Objectives

Accumulating evidence has implicated that brain derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of depression, but its correlation with ketamine's antidepressant efficacy focusing on Chinese individuals with depression is not known. This study was aim to determine the correlation of plasma BDNF (pBDNF) concentrations and ketamine's antidepressant efficacy.

Methods

Ninety-four individuals with depression received six intravenous infusions ketamine (0.5 mg/kg). Remission and response were defined as Montgomery-Asberg Depression Rating Scale (MADRS) scores less than 10 and a reduction of 50% or more in MADRS scores, respectively. Plasma was collected at baseline and at 24 h and 2 weeks after completing six ketamine infusions (basel

SUBMITTER: Zheng W 

PROVIDER: S-EPMC8015784 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature