Acute Systemic Experimental Inflammation Does Not Reduce Human Odor Identification Performance.

ABSTRACT: Olfactory dysfunction is a common symptom of various diseases, but the underlying pathophysiology has not been fully understood. Evidence from both animal and human studies suggests that local inflammation of the olfactory epithelium is linked to olfactory dysfunction. However, whether systemic inflammation causes olfactory dysfunction is yet to be determined. In the present behavioral study, we set out to test whether acute systemic inflammation impairs olfactory identification performance by inducing a transient and controlled state of systemic inflammation using an experimental endotoxemia model. We treated young healthy participants (N = 20) with a relatively high dose (2.0 ng/kg) of lipopolysaccharide (LPS) and a placebo treatment in a double-blind within-subject design, and assessed

SUBMITTER: Tognetti A 

PROVIDER: S-EPMC8015794 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature