HILPDA Is a Prognostic Biomarker and Correlates With Macrophage Infiltration in Pan-Cancer.

ABSTRACT: Background: The protein hypoxia-inducible lipid droplet-associated (HILPDA) is differentially expressed in various tumors. However, its role and correlation with immune cell infiltration in most tumors remain unclear. Methods: HILPDA expression was analyzed in pan-cancer data from The Cancer Genome Atlas (TCGA) database. The influence of HILPDA in clinical prognosis was evaluated using clinical survival data from TCGA. Enrichment analysis of HILPDA was conducted using the R package "clusterProfiler." We downloaded the immune cell infiltration score of TCGA samples from published articles and analyzed the correlation between the magnitude of immune cell infiltration and HILPDA expression. Results: HILPDA was highly expressed and associated with worse overall survival, d

SUBMITTER: Liu C 

PROVIDER: S-EPMC8015804 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature