Associations between urinary 6-sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes.

ABSTRACT:

Aims/introduction

There are limited reports on the association between melatonin levels and vascular complications in patients with type 2 diabetes. The aim of this study was to determine the association between urinary 6-sulfatoxymelatonin, which is a urinary metabolite of melatonin, and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes.

Materials and methods

This retrospective study included patients (167 patients with type 2 diabetes and 27 patients without diabetes adjusted for age and sex) admitted to the hospital who underwent measurement of urinary 6-sulfatoxymelatonin. The urinary 6-sulfatoxymelatonin/creatinine ratio (6-SMT) was calculated.

Results

The natural logarithmically scaled 6-SMT level (Ln 6-SMT) was significantly l

SUBMITTER: Tanaka K 

PROVIDER: S-EPMC8015816 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature