Relationships between gut microbiota, plasma glucose and gestational diabetes mellitus.

ABSTRACT:

Aims/introduction

To investigate the changes in the gut microbiome in the second trimester of pregnancy associated with later-diagnosed gestational diabetes mellitus (GDM) and their relationship with fasting serum levels of metabolites, especially glucose.

Materials and methods

We carried out a case-control study with 110 GDM patients and 220 healthy pregnant women who provided fecal samples for 16S ribosomal ribonucleic acid sequencing in the second trimester of pregnancy.

Results

Our results showed that GDM patients had lower α-diversity that was significantly associated with glycemic traits. Principal coordinates analysis showed significantly different microbial communities, as within GDM patients, seven genera within the phylum Firmicutes and two within the phylum

SUBMITTER: Chen T 

PROVIDER: S-EPMC8015828 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature