White matter microstructure disruption in early stage amyloid pathology.

ABSTRACT:

Introduction

Amyloid beta (Aβ) accumulation is the first pathological hallmark of Alzheimer's disease (AD), and it is associated with altered white matter (WM) microstructure. We aimed to investigate this relationship at a regional level in a cognitively unimpaired cohort.

Methods

We included 179 individuals from the European Medical Information Framework for AD (EMIF-AD) preclinAD study, who underwent diffusion magnetic resonance (MR) to determine tract-level fractional anisotropy (FA); mean, radial, and axial diffusivity (MD/RD/AxD); and dynamic [¹⁸F]flutemetamol) positron emission tomography (PET) imaging to assess amyloid burden.

Results

Regression analyses showed a non-linear relationship between regional amyloid burden and WM microstructure. Low amylo

SUBMITTER: Collij LE 

PROVIDER: S-EPMC8015832 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature