Characterization of transcripts emanating from enhancer Eβ of the murine TCRβ locus.

ABSTRACT: Enhancers are well established as critical regulators of gene expression, but the mechanisms underlying the molecular basis of their specificity and activity are only partly understood. One of the most exciting recent observations is the discovery of enhancer RNA (eRNA), a class of noncoding RNAs derived from enhancer regions. Transcription of developmentally regulated enhancers has been observed to be associated with their active state. The nature of transcripts (eRNA) and their functional attributes are diverse and context dependent. The majority of eRNA are nonpolyadenylated and present in low abundance owing to their low stability, and may represent transcriptional noise. However, some eRNAs have been reported to be reasonably long and stable, are enriched in nuclei, exhibit tissue-spe

SUBMITTER: Uddin F 

PROVIDER: S-EPMC8016127 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature