Analysis of the role of Frizzled 2 in different cancer types.

ABSTRACT: Frizzled 2 (FZD2) is an important receptor in the Wnt pathway, which is highly expressed in malignant tumors and helps regulate multiple tumor behaviors. Its expression level is related to prognosis. Here, bioinformatic analysis was performed to understand the expression of FZD2 in different tumors. We examined FZD2 expression using pan-cancer data of 33 cancer types from The Cancer Genome Atlas (TCGA). Differential expression analysis (Wilcoxon's test) was used to compare tumor and normal tissues. Univariate Cox proportional hazard regression was performed to compare gene expression and overall patient survival. COSMIC, cBioPortal, and CCLE were used to examine FZD2 mutations in human cancers. Dryness index was calculated using one-class logistic regression (OCLR). Spearman's correlation

SUBMITTER: Zhou M 

PROVIDER: S-EPMC8016138 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature