Drop-of-blood acoustic tweezing technique for integrative turbidimetric and elastometric measurement of blood coagulation.

ABSTRACT: Many patients develop coagulation abnormalities due to chronic and hereditary disorders, infectious disease, blood loss, extracorporeal circulation, and oral anticoagulant misuse. These abnormalities lead to bleeding or thrombotic complications, the risk of which is assessed by coagulation analysis. Current coagulation tests pose safety concerns for neonates and small children due to large sample volume requirement and may be unreliable for patients with coagulopathy. This study introduces a containerless drop-of-blood method for coagulation analysis, termed "integrated quasi-static acoustic tweezing thromboelastometry" (i-QATT™), that addresses these needs. In i-QATT™, a single drop of blood is forced to levitate and deform by the acoustic radiation force. Coagulation-induced changes in d

SUBMITTER: Luo D 

PROVIDER: S-EPMC8016159 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature