A library of coiled-coil domains: from regular bundles to peculiar twists.

ABSTRACT:

Motivation

Coiled coils are widespread protein domains involved in diverse processes ranging from providing structural rigidity to the transduction of conformational changes. They comprise two or more α-helices that are wound around each other to form a regular supercoiled bundle. Owing to this regularity, coiled-coil structures can be described with parametric equations, thus enabling the numerical representation of their properties, such as the degree and handedness of supercoiling, rotational state of the helices, and the offset between them. These descriptors are invaluable in understanding the function of coiled coils and designing new structures of this type. The existing tools for such calculations require manual preparation of input and are therefore not suitable for the hi

SUBMITTER: Szczepaniak K 

PROVIDER: S-EPMC8016460 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature