Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers.

ABSTRACT: Behavioral specialization is key to the success of social insects and leads to division of labor among colony members. Response thresholds to task-specific stimuli are thought to proximally regulate behavioral specialization, but their neurobiological regulation is complex and not well understood. Here, we show that response thresholds to task-relevant stimuli correspond to the specialization of three behavioral phenotypes of honeybee workers in the well-studied and important Apis mellifera and Apis cerana. Quantitative neuropeptidome comparisons suggest two tachykinin-related peptides (TRP2 and TRP3) as candidates for the modification of these response thresholds. Based on our characterization of their receptor binding and downstream signaling, we confirm a functional role o

SUBMITTER: Han B 

PROVIDER: S-EPMC8016481 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature