RANK promotes colorectal cancer migration and invasion by activating the Ca²⁺-calcineurin/NFATC1-ACP5 axis.

ABSTRACT: The tumor necrosis factor (TNF) receptor superfamily member 11a (TNFRSF11a, also known as RANK) was demonstrated to play an important role in tumor metastasis. However, the specific function of RANK in colorectal cancer (CRC) metastasis and the underlying mechanism are unknown. In this study, we found that RANK expression was markedly upregulated in CRC tissues compared with that in matched noncancerous tissues. Increased RANK expression correlated positively with metastasis, higher TNM stage, and worse prognosis in patients with CRC. Overexpression of RANK promoted CRC cell metastasis in vitro and in vivo, while knockdown of RANK decreased cell migration and invasion. Mechanistically, RANK overexpression significantly upregulated the expression of tartrate-resistant acid phosphatase 5 (TR

SUBMITTER: Liang Q 

PROVIDER: S-EPMC8016848 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature