Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China.

ABSTRACT: We investigated cross-sectional associations between children's neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed using 16S rRNA gene profiling. Microbial diversity was characterized using alpha diversity patterns. Additionally, 3 coabundance factors were determined for the 25 most abundant taxa. Multivariable linear regression models were constructed to examine the relationships between Bayley scores (MDI and PDI) and children's gut microbiota. In adjusted models, MDI and PDI scores were not associated wit

SUBMITTER: Rothenberg SE 

PROVIDER: S-EPMC8016964 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature