Looking backward to move forward: a meta-analysis of stem cell therapy in amyotrophic lateral sclerosis.

ABSTRACT: Transplantation of several types of stem cells (SC) for the treatment of amyotrophic lateral sclerosis (ALS) has been evaluated in numerous Phase I/II clinical trials with inconclusive results. Here, we conducted a meta-analysis to systematically assess the outcome of SC therapy trials which report the evolution of each patient before and after cell administration. In this way, we aimed to determine the effect of the SC intervention despite individual heterogeneity in disease progression. We identified 670 references by electronic search and 90 full-text studies were evaluated according to the eligibility criteria. Eleven studies were included comprising 220 cell-treated patients who received mesenchymal (M) SC (n = 152), neural (N) SC (n = 57), or mononuclear cells (MNC: CD34, CD117, and

SUBMITTER: Morata-Tarifa C 

PROVIDER: S-EPMC8016966 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature