Expansion of Functional Myeloid-Derived Suppressor Cells in Controlled Human Malaria Infection.

ABSTRACT: Malaria can cause life-threatening complications which are often associated with inflammatory reactions. More subtle, but also contributing to the burden of disease are chronic, often subclinical infections, which result in conditions like anemia and immunologic hyporesponsiveness. Although very frequent, such infections are difficult to study in endemic regions because of interaction with concurrent infections and immune responses. In particular, knowledge about mechanisms of malaria-induced immunosuppression is scarce. We measured circulating immune cells by cytometry in healthy, malaria-naïve, adult volunteers undergoing controlled human malaria infection (CHMI) with a focus on potentially immunosuppressive cells. Infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Cha

SUBMITTER: Lamsfus Calle C 

PROVIDER: S-EPMC8017236 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature