Human PD-1^hiCD8⁺ T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune disease in which T-B interactions play a critical role. Recent comprehensive analysis suggests that PD-1⁺CD8⁺ T cells as well as two distinct IL-21-producing PD-1⁺CD4⁺ T cell subsets, follicular helper T (Tfh) and peripheral helper T (Tph) cells, are involved in the pathogenesis of RA. Herein, we aimed to clarify a generation mechanism of IL-21-producing CD8⁺ T cells in humans, and to characterize this novel subset in patients with RA.

Methods

CD8⁺ T cells in the peripheral blood (PB) and synovial fluid (SF) of healthy control (HC) and patients with RA were subject to the analysis of IL-21 mRNA and protein. We evaluated the s

SUBMITTER: Higashioka K 

PROVIDER: S-EPMC8017303 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature