Exploring Common Therapeutic Targets for Neurodegenerative Disorders Using Transcriptome Study.

ABSTRACT: Alzheimer's disease (AD) and Parkinson's disease (PD) are well-known neuronal degenerative disorders that share common pathological events. Approved medications alleviate symptoms but do not address the root cause of the disease. Energy dysfunction in the neuronal population leads to various pathological events and ultimately results in neuronal death. Identifying common therapeutic targets for these disorders may help in the drug discovery process. The Brodmann area 9 (BA9) region is affected in both the disease conditions and plays an essential role in cognitive, motor, and memory-related functions. Analyzing transcriptome data of BA9 provides deep insights related to common pathological pathways involved in AD and PD. In this work, we map the preprocessed BA9 fastq files generated by RN

SUBMITTER: Dharshini SAP 

PROVIDER: S-EPMC8017312 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature