HLA Alleles B^*53:01 and C^*06:02 Are Associated With Higher Risk of <i>P. falciparum</i> Parasitemia in a Cohort in Uganda.

ABSTRACT: Variation within the HLA locus been shown to play an important role in the susceptibility to and outcomes of numerous infections, but its influence on immunity to P. falciparum malaria is unclear. Increasing evidence indicates that acquired immunity to P. falciparum is mediated in part by the cellular immune response, including NK cells, CD4 and CD8 T cells, and semi-invariant γδ T cells. HLA molecules expressed by these lymphocytes influence the epitopes recognized by P. falciparum-specific T cells, and class I HLA molecules also serve as ligands for inhibitory receptors including KIR. Here we assessed the relationship of HLA class I and II alleles to the risk of P. falciparum infection and symptomatic malaria in a cohort of 892 Ugandan children and adults foll

SUBMITTER: Digitale JC 

PROVIDER: S-EPMC8017319 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature