Association Between Obesity and Histological Tumor Budding in Patients With Nonmetastatic Colon Cancer.

ABSTRACT:

Importance

Obesity is associated with increased risk of colorectal cancer (CRC) and a more aggressive disease course. Tumor budding (TB) is an important prognostic factor for CRC, but its association with obesity is unknown.

Objective

To evaluate the association of TB with obesity and other prognostic factors in colon cancer.

Design, setting, and participants

This cohort study involved a histological review of colon cancer specimens obtained during 7 years (January 2008 to December 2015) at the University of Kentucky Medical Center; data analysis was conducted from February 2020 to January 2021. Specimens came from 200 patients with stage I to III colon cancer; patients with stage 0, stage IV, or incomplete data were excluded.

Main outcomes and measures

TB was

SUBMITTER: Gan T 

PROVIDER: S-EPMC8017472 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature