Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program.

ABSTRACT: Rationale: Some reports indicate longitudinal variability in sputum differential cell counts, whereas others describe stability. Highly variable sputum eosinophil percentages are associated with greater lung function loss than persistently elevated eosinophil percentages, but elevated neutrophils are linked to more severe asthma.Objectives: To examine sputum granulocyte stability or variability longitudinally and associations with important clinical characteristics.Methods: The SARP III (Severe Asthma Research Program III) cohort underwent comprehensive phenotype characterization at baseline and annually over 3 years. Adult subjects with acceptable sputum levels were assigned to one of three longitudinal sputum groups: eosinophils predominantly <2%, eosinophils predomi

SUBMITTER: Hastie AT 

PROVIDER: S-EPMC8017570 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature